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ERBB2 p.L755S Reference Standard

CBP10270

產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
Introduction 
Format Genomic DNA
Description ERBB2 (HER2) L755S lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). L755S results in increased phosphorylation of Erbb2 (Her2), activation of downstream signaling, is transforming in cell culture (PMID: 29967253), and is associated with resistance to Erbb2 (Her2)-targeted therapies (PMID: 22046346, PMID: 28487443).
   
Technical Data 
DNA Change c.2264T>C
AA Change p.L755S
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50%
Transcript ENST00000269571
Cosmic ID N/A
Chr position(GRCh37) chr17:37880220
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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