CDKN2A Loss Reference Standard
CBP40050
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產品描述
產品數據庫
| Introduction | ||
| Format | Genomic DNA | |
| Description | CDKN2A, cyclin-dependent kinase inhibitor 2A, is a tumor suppressor (PMID: 30562755) that encodes p16 and p14ARF from alternate reading frames, which function to inhibit Cdk4 and Cdk6 and regulate Tp53 activity to promote cell-cycle arrest (PMID: 23875803, PMID: 17055429, PMID: 27428416). CDKN2A germline mutations are associated with familial atypical multiple mole melanoma and somatic mutations are highest in pancreatic (PMID: 32273725), HNSCC, NSCLC, and melanoma (PMID: 27283171), and deletion of CDKN2A may be prognostic in IDH-mutant glioma (PMID: 32385699). | |
| Technical Data | ||
| Measured CNV | 0 | |
| Definition | Loss | |
| Buffer | Tris-EDTA | |
| Ploidy | 2.76 | |
| Product Information | ||
| Intended Use | Research Use Only | |
| Unit Size | 1ug | |
| Concentration | Download for COA | |
| Purity | Download for COA | |
| DNA electrophoresis | Download for COA | |
| Sanger sequencing | Download for COA | |
| Storage | 4℃ | |
| Expiry | 36 months from the date of manufacture | |
