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首頁 /藥靶模型 /藥靶細(xì)胞 /GPCR靶點(diǎn) /CCR1/CHO

CCR1/CHO

CBP71353

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I. Background

C-C chemokine receptor type 1 (CCR1) is a G protein-coupled receptor member of the CC chemokine subfamily of
receptors. Following interaction with its specific chemokine ligands, like macrophage inflammatory protein 1 alpha
(MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), and monocyte
chemoattractant protein 3 (MCP-3), it triggers the onset of a process known as chemotaxis. 

 
II. Introduction
Host Cell:

CHO

Stability: 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: F12K+10%FBS+5ug/ml puromycin
Mycoplasma Status: Negative
Storage: Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for CCR1 receptor

Transducer: Gi
 
Ⅲ. Description of Host Cell Line
Organism: Hamster
Tissue: Ovary
Morphology: Epithelial
Growth Properties: Adherent
 
Ⅳ. Representative Data

Figure 1. Recombinant CCR1/CHO constitutively expressing CCR1.

Figure 2. CCL3 effect on CHO-K1-CCR1 clone 6.


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