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首頁(yè) /藥靶模型 /藥靶細(xì)胞 /GPCR靶點(diǎn) /EDNRA/CHO

EDNRA/CHO

CBP71373

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I. Background
EDNRA (Endothelin Receptor Type A) is a Protein Coding gene. Diseases associated with EDNRA include Mandibulofacial Dysostosis With Alopecia and Migraine With Or Without Aura 1. Among its related pathways are Development Endothelin-1/EDNRA transactivation of EGFR and Class A/1 (Rhodopsin-like receptors). Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and endothelin receptor activity. 
 
II. Introduction
Host Cell:

CHO

Stability: 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: F12K+10%FBS+5ug/ml puromycin
Mycoplasma Status: Negative
Storage: Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for EDNRA receptor

Transducer: Gq
 
Ⅲ. Description of Host Cell Line
Organism: Hamster
Tissue: Ovary
Morphology: Epithelial
Growth Properties: Adherent
 
Ⅳ. Representative Data

 


Figure 1. Recombinant EDNRA/CHO constitutively expressing EDNRA.

Figure 2. Endothelin 1 efffect on CHO-EDNRA clone 6.

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