EOMA（小鼠血管內皮瘤細胞）
CBP61138
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| I. General information | |
| Synonyms: | EOMA |
| Background: | The EOMA cell line was originally derived in 1980 from a mixed hemangioendothelioma arising in an adult mouse. |
| Species: | Mus musculus, mouse |
| Tissue: | tumor |
| Disease: | hemangioendothelioma |
| Gender: | adult |
| Morphology: | endothelial |
| Growth Mode: | adherent |
| Doubling Time: | N/A |
| DNA Profile: | N/A Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
DMEM+10%FBS EOMA完全培養(yǎng)基，# CBP61138M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | CD31 + vascular addressin + CD45 (Ly5-T200) + |
| Receptor Expression: | acetylated low density liproprotein Ref |
| Oncogene: | N/A |
| Genes Expressed: | angiotensin converting enzyme (ACE) thrombospondin cathepsin L endostatin interleukin-6 (interleukin 6, IL-6) |
| Cellular Products: | angiotensin converting enzyme (ACE) thrombospondin cathepsin L endostatin interleukin-6 (interleukin 6, IL-6) |
| Tumor Formation: | Yes, in syngeneic mice |
| Comments: | The cells synthesize angiotensin-converting enzyme, express surface receptors for acetylated low density lipoprotein, produce thrombospondin and show intracellular staining with an antibody to von Willebrand factor. Cathepsin L is secreted by EOMA cells and is responsible for the generation of endostatin L. Although constitutive cytokine gene expression exists in EOMA cells, the level of IL-6 mRNA is prominently elevated by incubation with Liposome encapsulated hemoglobin (LEH). The cells constitutively express the vascular addressin identified by antibody MECA-99. EOMA cells exhibit characteristic endothelial cell properties, such as rearrangement into tubelike structures on Matrigel and retention of cobblestone morphology at confluence. They behave in vitro in a manner similar to microvascular endothelial cells. For more information, please contact Cobioer (4008-750-250). |
