NGF/Canine TRKA Effector Reporter Cell
CBP74230
| I. Background | |
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NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3. TrkA gene expression is under positive feedback from NGF signaling, and this pathway most likely is disrupted in AD by diminished retrograde transport of cortical NGF to CBF consumer neurons. |
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| II.Introduction | |
| Expressed gene: | NGF/Canine TRKA |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | nerve growth factor (beta polypeptide), NGFB |
| Freeze Medium: | 90% FBS+10%DMSO |
| Culture Medium: | DMEM+10%FBS+2ug/ml puromycin+200ug/ml hygromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
Figure 1.Dose Response of Recombinant Human NGF in NGF/Canine TRKA Effector Reporter Cells (C19).
Figure 2. Inhibition of NGF-induced Reporter Activity by Canine NGF Neutralization Ab in NGF/Canine TRKA Effector Reporter Cels (C19).
