hCDH6/RENCA
CBPG0090
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產(chǎn)品描述
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| I. Background | |
| CDH6（Cadherin 6,鈣粘蛋白 6） 是一種 II 型鈣粘附素，是鈣粘附素家族的成員之一。 CDH6 對(duì)于細(xì)胞黏附、胚胎發(fā)育的細(xì)胞識(shí)別、遷移和組織分化、構(gòu)成成體器官都有重要作 用。在胚胎發(fā)育過程中，參與胚胎腎形態(tài)形成和發(fā)育，驅(qū)動(dòng)腎形態(tài)發(fā)生所需的間充質(zhì)-上皮 分化。CDH6 在甲狀腺腫瘤、膽管癌、骨肉瘤、口腔鱗狀細(xì)胞癌、黑色素瘤、甲狀腺乳頭 狀癌、鼻咽癌、膠質(zhì)瘤、胃癌等腫瘤中起到重要作用。CDH6 還可以作為甘氨酰-tRNA 合 成酶（GRS）的功能性受體在人體內(nèi)部起到抗腫瘤作用。 | |
| II. Introduction | |
| Host Cell: | RENCA |
| Expressed gene: | hCDH6 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS + 1% Non Essential Amino Acids (NEAA) + 1mM Sodium Pyruvate (NaP)+2ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | kidney |
| Morphology: | epithelial-like |
| Growth Properties: | adherent |
| IV. Representative Data | |
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Figure 1. Recombinant hCDH6/RENCA stably expressing CDH6. |
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