hDLL3/KLN205
CBPG0126
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產(chǎn)品描述
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I. Background | |
DLL3 基因別名 SCDO1,其編碼的蛋白 DLL3 是一種跨膜蛋白,是 Notch 受體配體 Delta/Serrate/lag2(DSL)組的成員,在胚層的分離中,影響著體細(xì)胞邊界的形成。 DLL3 基因突變會導(dǎo)致嚴(yán)重的體節(jié)發(fā)生異常和脊椎肋骨發(fā)育不全。DLL3 是一種高度腫瘤選 擇性的細(xì)胞表面靶點(diǎn),在正常肺癌組織及癌旁組織中不表達(dá)。DLL3 在多種腫瘤中表達(dá)上 調(diào),在小細(xì)胞肺癌、乳腺癌、垂體瘤、急性髓系白血病中有促癌作用,但在肝癌 、神經(jīng)膠 質(zhì)瘤和惡性膠質(zhì)瘤中卻發(fā)揮了抑癌作用。 | |
II. Introduction | |
Host Cell: | KLN205 |
Expressed gene: | hDLL3 |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | MEM+ 10% FBS+ 1% Non Essential Amino Acids (NEAA) + 1mM Sodium Pyruvate (NaP) +2μg/ml puromycin |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
III. Description of Host Cell Line | |
Organism: | Mus musculus, mouse |
Tissue: | Lung |
Morphology: | Epithelial |
Growth Properties: | Adherent |
IV. Representative Data | |
Figure 1. Recombinant hDLL3/KLN205 stably expressing hDLL3. |
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