PDGFRA V658A-V561A/BaF3
CBP73378
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| I. Introduction | |
| Cell Line Name： | PDGFRA V658A-V561A/BaF3 |
| Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Complete Culture Medium: | RPMI-1640+10%FBS |
| Mycoplasma Status: | Negative |
| II. Background | |
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PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035). |
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| III. Representative Data | |
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1.Sanger of PDGFRA V658A-V561A/BaF3
Figure 1. PDGFRA V658A-V561A/BaF3 V658A
Figure 2. PDGFRA V658A-V561A/BaF3 V561A |
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2. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of PDGFRA V561A/V658A BaF3 Cells (C2). |
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