MC/CAR（人外周血多發(fā)性骨髓瘤細(xì)胞）
CBP60821
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| I. General information | |
| Synonyms: | MC/CAR |
| Background: | Although derived from cells taken from a patient with a plasmacytoma, this line has been shown to be an EBV-transformed B lymphoblastoid cell line. |
| Species: | Homo sapiens, human |
| Tissue: | peripheral blood |
| Disease: | plasmacytoma; myeloma |
| Gender: | male, 81 years, Caucasian |
| Morphology: | lymphoblast |
| Growth Mode: | suspension |
| DNA Profile: | Amelogenin: X,Y CSF1PO: 11,12 D13S317: 11,13 D16S539: 11,12 D5S818: 11,14 D7S820: 9,13 THO1: 6,9 TPOX: 8 vWA: 17,18 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
IMDM+20%FBS MC/CAR完全培養(yǎng)基，# CBP60821M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | HLA A1, A33/31, B7, B18, DRw1, DRw2; CD11a +; CD19 +; CD20 + CD28 -; CD38 + |
| Receptor Expression: | complement (C3b) |
| Genes Expressed: | immunoglobulin |
| Cellular Products: | immunoglobulin |
| Tumor Formation: | Yes, in nude mice inoculated subcutaneously with 107 cells (Tumors developed within 21 days at 100% frequency (5/5).) |
| Comments: | The cells produce, but do not secrete, immunoglobulin. No surface immunoglobulin. 8-azaguanine mutants may be cloned out or mutagenized for HAT sensitive cultures. For more information, please contact Cobioer (4008-750-250). |
