hIL20/IL22/IL24 Triple Effector Reporter Cell
CBP74228
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| I. Background | |
| IL-20, IL-22, and IL-24 are closely related cytokines that belong to the IL-20 subfamily and play an important role in the protection of barrier tissues. They share the heterodimeric IL-20 type I and type II receptors composed of the IL-20Rα and IL-20Rβ chains, and IL-22Rα1 and IL-20Rβ chains, respectively. | |
| II. Introduction | |
| Expressed gene: | IL20R、IL22R、IL24R |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2ug/ml puromycin+200ug/ml hygromycin+5ug/ml blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
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Figure 1. Recombinant hIL20/IL22/IL24 Triple Effector Reporter Cell stably expressing IL22Rα. |
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Figure 2. Dose Response of Ligands in hlL20/IL22/lL24 Triple Effector Reporter Cells (C30). |
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Figure 3. Inhibition of Human lL22-induced Reporter Activity by lL22Ra Blocking Ab or lL22 Neutralization Ab in hIL20/IL22/IL24 Triple Effector Reporter Cells (C30). |
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Figure 4. Inhibition of Human lL20-induced Reporter Activity by lL20 Neutralization Ab in hlL20/IL22/IL24 Triple Effector Reporter Cells(C30). |
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