pCBRG-XRE
CBV20010
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| Introduction | |
| Description: | pXRE-Luc is designed for monitoring the induction of xenobiotic stress element.The classical recognition motif of the AhR/ARNT complex, referred to as either the AhR-, dioxin- or xenobiotic- responsive element (AHRE, DRE or XRE), contains the core sequence 5'-GCGTG-3' within the consensus sequence 5'-T/GNGCGTGA/CG/CA-3' in the promoter region of AhR responsive genes. The AhR/ARNT heterodimer directly binds the AHRE/DRE/XRE core sequence in an asymmetric manner such that ARNT binds to 5'-GTG-3' and AhR binding 5'-TC/TGC-3'. Recent research suggests that a second type of element termed AHRE-II, 5'-CATG(N6)C[T/A]TG-3', is capable of indirectly acting with the AhR/ARNT complex. Regardless of the response element, the end result is a variety of differential changes in gene expression. |
| Plasmid profile: |  |
| Unit Size: | 1-4μg |
| Pathway (Activitor): | Xenobiotic stress |
| Pathway profile: |  |
| Full Name: | Aryl hydrocarbon receptor |
| Cis response element: | XRE (Xenobiotic stress element) |
| Shelf Life: | One year from date of receipt under proper storage conditions. |
| Storage: | -20°C |
| Mode of transportation: | Ice bag transport |
| Matters needing attention: | For your health, please wear lab clothes and disposable gloves. |
