pCBRG- STAT3 RE
CBV20044
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| Introduction | |
| Description: | pSTAT3 RE-Luc is designed for monitoring the induction of Signal transducer and activator of transcription 3.STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), form homo- or heterodimers, and translocate to the cell nucleus where they act as transcription activators. Specifically, STAT3 becomes activated after phosphorylation of tyrosine 705 in response to such ligands as interferons, epidermal growth factor (EGF), Interleukin (IL-)5 and IL-6. Additionally, activation of STAT3 may occur via phosphorylation of serine 727 by Mitogen-activated protein kinases (MAPK) and through c-src non-receptor tyrosine kinase.STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. |
| Plasmid profile: |  |
| Unit Size: | 1-4μg |
| Pathway (Activitor): | STAT3 |
| Pathway profile: |  |
| Full Name: | Signal transducer and activator of transcription 3 |
| Cis response element: | stat3 RE |
| Shelf Life: | One year from date of receipt under proper storage conditions. |
| Storage: | -20°C |
| Mode of transportation: | Ice bag transport |
| Matters needing attention: | For your health, please wear lab clothes and disposable gloves. |
