SK-BR-3(人乳腺腺癌細(xì)胞)
CBP60413
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I. General information | |
Synonyms: | SK-BR-3 |
Background: | This cell line was derived by G. Trempe and L. J. Old in 1970 from pleural effusion cells of a patient, a White, Caucasian female, age 43, blood type A+, who had been treated with radiation, steroids, cytoxan and 5-fluorouracil. |
Species: | Homo sapiens, human |
Tissue: | mammary gland/breast; derived from metastatic site: pleural effusion |
Disease: | adenocarcinoma |
Gender: | female, Caucasian, 43 years |
Morphology: | epithelial |
Growth Mode: | adherent |
Doubling Time: | N/A |
DNA Profile: | Amelogenin: X CSF1PO: 12 D13S317: 11,12 D16S539: 9 D5S818: 9,12 D7S820: 9,12 THO1: 8,9 TPOX: 8,11 vWA: 17 Cobioer’s Cell Line Authentication Service |
Isoenzymes: | AK-1, 1-2 ES-D, 1 G6PD, B GLO-I, 2 PGM1, 1-2 PGM3, 1 |
Culture Medium: |
McCoy's 5a+10%FBS SK-BR-3完全培養(yǎng)基,# CBP60413M |
Cryopreservation medium: | 90%FBS+10%DMSO |
Antigen Expression: | Blood Type A; Rh+; HLA A11, Bw22(+/-), B40, B18 |
Receptor Expression: | N/A |
Oncogene: | N/A |
Genes Expressed: | N/A |
Cellular Products: | N/A |
Tumor Formation: | Yes, in nude mice; forms poorly differentiated adenocarcinoma |
Comments: | The patient, a White, Caucasian female, age 43, blood type A+, had been treated with radiation, steroids, cytoxan and 5-fluorouracil. No virus particles. Ultrastructural features include microvilli and desmosomes, glycogen granules, large lysosomes, bundles of cytoplasmic fibrils. The SK-BR-3 cell line overexpresses the HER2/c-erb-2 gene product. For more information, please contact Cobioer (4008-750-250). |