CD161 Effector Reporter Cell
CBP74137
| I. Background | |
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NK 細胞受體(Natural killer -cell receptor, NKRs)表達于 NK 細胞和 T 細胞表面，參與調(diào) 節(jié)下游信號的激活和抑制，積極參與免疫應(yīng)答的調(diào)節(jié)。它們具有 C 型凝集素樣結(jié)構(gòu)域，該 結(jié)構(gòu)域失去了結(jié)合 Ca 2+的能力，參與蛋白質(zhì)-蛋白質(zhì)相互作用，而不是碳水化合物結(jié)合。 |
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| II. Description | |
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CD161 Effector Reporter Cell 報告基因藥靶模型很好的模擬了體內(nèi) CD161 的信號轉(zhuǎn)導(dǎo) 過程，原理見下圖所示。
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| III. Introduction | |
| Expressed gene: |
CD161 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
RPMI-1640+10%FBS+800 μg/ml hygromycin+1 μg/ml puromycin
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| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Representative Data | |
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Figure 1. Dose Response of CD161 Blocking Antibody in CD161 Effector Reporter Cells (Clone 8) With CLEC2D aAPC Cells. |
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