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首頁(yè) /藥靶模型 /藥靶細(xì)胞 /激酶靶點(diǎn) /TEL(ETV6)-JAK2/BaF3

TEL(ETV6)-JAK2/BaF3

CBP73117

產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
I. Introduction
Cell Line Name: TEL(ETV6)-JAK2/BaF3
Host Cell: Ba/F3
Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application: This kit is useful for screening for small molecules displacing ATP from the JH2 domain of JAK2.
Freeze Medium: 90% FBS+10% DMSO
Complete Culture Medium: RPMI-1640+10%FBS+2ug/ml puromycin
Mycoplasma Status: Negative
 
II. Background

JAK2, Janus kinase 2, is a non-receptor protein tyrosine kinase that binds cytokine receptors to activate the interferon-alpha/beta/gamma pathway and is a member of the JAK/STAT signaling pathway (PMID: 15575979, PMID: 30092288). JAK2 mutations are observed in a variety of tumor types, including myeloproliferative neoplasms (PMID: 30074114), lymphoma (PMID: 29984752), leukemia (PMID: 29979407), and cervical cancer (PMID: 30003068). 

 
III. Representative Data

1.WB of BA/F3/TEL(ETV6)-JAK2

 

2. Anti-proliferation assay

 

Figure 2. CTG Proliferation Assay of BaF3 TEL-JAK2 (C1).

 

藥靶模型聯(lián)系方式: 華東銷(xiāo)售經(jīng)理:18240630236 全國(guó)銷(xiāo)售經(jīng)理:18066071954
診斷標(biāo)準(zhǔn)品聯(lián)系方式: 華東銷(xiāo)售經(jīng)理:15000320447 華北銷(xiāo)售經(jīng)理:18131625521 華南銷(xiāo)售經(jīng)理:13484295986 華中&西南銷(xiāo)售經(jīng)理:13871580511 全國(guó)銷(xiāo)售經(jīng)理:13484295986

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