EML4-ALK V1 [G1202R/G1269A] /BaF3
CBP73273
| I. Introduction | |
|
Cell Line Name： |
EML4-ALK V1 [G1202R/G1269A] /BaF3 |
|
Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
|
Application: |
Anti-proliferation assay and PD assay |
|
Freeze Medium: |
90% FBS+10% DMSO |
|
Complete Culture Medium: |
RPMI-1640+10%FBS+2ug/ml puromycin |
|
Mycoplasma Status: |
Negative |
| II. Background | |
|
EML4-ALK results from the fusion of EML4 and ALK, resulting in constitutive kinase activity, transformation in cultured cells, and tumor activity in mouse models (PMID: 19064915, PMID: 17625570). EML4-ALK fusions have been associated with non-small cell lung cancer (PMID: 26755435). |
|
| III. Representative Data | |
|
1.WB of EML4-ALK V1 [G1202R/G1269A] /BaF3
|
|
|
2. EML4-ALK V1 [G1202R/G1269A] /BaF3
Figure 2. EML4-ALK V1 [G1202R/G1269A] /BaF3 Fusion
Figure 3. EML4-ALK V1 [G1202R/G1269A] /BaF3 G1202R
Figure 4. EML4-ALK V1 [G1202R/G1269A] /BaF3 G1269A |
|
|
2. Anti-proliferation assay
Figure 5. CTG Proliferation Assay of EML4-ALK V1 [G1202R/G1269A] /BaF3. |
|
