c-Kit D816H/BaF3
CBP73282
詢 價
留 言
產品描述
產品數(shù)據庫
| I. Introduction | |
|
Cell Line Name： |
c-Kit D816H/BaF3 |
|
Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
|
Application: |
Anti-proliferation assay and PD assay |
|
Freeze Medium: |
90% FBS+10% DMSO |
|
Complete Culture Medium: |
RPMI-1640+10%FBS |
|
Mycoplasma Status: |
Negative |
| II. Background | |
|
KIT D816H lies within the tyrosine kinase domain region 2 (exon 17) of the Kit protein (PMID: 19164557). D816H results in increased kinase activity, constitutive Kit phosphorylation, activation of Stat3 signaling, and transformation of cultured cells (PMID: 10362788, PMID: 11494148), and confers resistance to some Kit inhibitors (PMID: 25239608). |
|
| III. Representative Data | |
|
1. WB of c-Kit D816H/BaF3
|
|
|
2. Sanger of c-Kit D816H/BaF3
|
|
|
3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 C-KlT D816H. |
|
