藥靶模型
Drug Target Model
藥靶模型
Drug Target Model
激酶(kinase)是一類非常重要的藥物靶點。許多腫瘤的發(fā)生是由某些與生長相關的“激酶”發(fā)生突變導致異?；罨鸬模蚨槍@些突變激酶的抑制劑能夠有效抑制這些激酶的活性，從而達到抑制癌細胞增長的目的。為了助力此類小分子藥物研發(fā)，科佰開發(fā)了BA/F3系列的激酶工程細胞株，用于評估藥物對激酶的靶向抑制作用。
c-Kit K642E/BaF3
CBP73332c-Kit V560Del/BaF3
CBP73314c-Kit L576P/BaF3
CBP73298c-Kit A502_Y503dup/BaF3
CBP73296c-Kit K642E-D816A/BaF3
CBP73294c-Kit W557G/BaF3
CBP73293c-Kit V559A/BaF3
CBP73286c-Kit W557_K558del-D816V/BaF3
CBP73285c-Kit W557_K558del-T670I/BaF3
CBP73284c-Kit W557_K558del-V654A/BaF3
CBP73283c-Kit D816H/BaF3
CBP73282c-Kit N822K/BaF3
CBP73279c-Kit D816Y/BaF3
CBP73276c-Kit WT (SCF1 Dependent)/BaF3
CBP73269c-Kit D820Y/BaF3
CBP73236c-Kit V560D/BaF3
CBP73235c-Kit V559D/BaF3
CBP73234c-Kit W557_K558del/BaF3
CBP73233c-Kit Y823D/BaF3
CBP73208c-Kit D816V/BaF3
CBP73206EGFR Del19-T790M-C797S/PC14
CBP73397EGFR L858R-T790M-C797S/BaF3
CBP73382EGFR/MDA-MB-231
CBP73349EGFR VIII/BaF3
CBP73226EGFR H773_V774insH/BaF3
CBP73224EGFR H773_V774insPHPH/BaF3
CBP73223EGFR V769_D770insGVV/BaF3
CBP73222EGFR V769_D770insSFL/BaF3
CBP73221EGFR H773_V774insAH/BaF3
CBP73220EGFR H773_V774insPH/BaF3
CBP73219EGFR D770_N771insY/BaF3
CBP73218EGFR V769_D770insGSV/BaF3
CBP73217EGFR L858R-T790M-C797S/NCI-H1975
CBP73213EGFR D770>GY/BaF3
CBP73183EGFR A763_Y764insFQEA/BaF3
CBP73182EGFR S768_V769delinsIL(S768I&V769L)/BaF3
CBP73181EGFR D770_N771insNPG/BaF3
CBP73180EGFR P772_H773insDNP/BaF3
CBP73179EGFR D770_N771insG/BaF3
CBP73178EGFR H773_V774insNPH/BaF3
CBP73177EGFR V769_D770insASV/BaF3
CBP73176EGFR D770_N771insSVD/BaF3
CBP73175EGFR Del19-T790M-C797S/BaF3
CBP73173EGFR Del19-C797S/BaF3
CBP73172EGFR S768I/BaF3
CBP73171EGFR G719A/BaF3
CBP73170EGFR G719S/BaF3
CBP73169EGFR G719D/BaF3
CBP73168EGFR WT (EGF Dependent)/BaF3_Discontinued
CBP73166EGFR WT (EGF Dependent) BaF3
CBP73399EGFR L861Q/BaF3
CBP73050EGFR L858R-T790M-C797S/BaF3_Discontinue
CBP73049EGFR L858R-T790M/BaF3
CBP73048EGFR L858R-C797S/BaF3
CBP73047EGFR Del19-T790M/BaF3
CBP73046EGFR Del19/BaF3
CBP73045EGFR L858R/BaF3
CBP73040EML4-ALK V1 [C1156Y/G1202R]/BaF3
CBP73364EML4-ALK V1 [I1171S]/BaF3
CBP73354EML4-ALK V1 [I1171T]/BaF3
CBP73353EML4-ALK V1 [L1196M/L1198F]/BaF3
CBP73352EML4-ALK V1 [C1156Y/L1198F]/BaF3
CBP73351EML4-ALK V1 [G1269S]/BaF3
CBP73350EML4-ALK V1 [L1198F]/BaF3
CBP73343EML4-ALK V1 [D1203N]/BaF3
CBP73342EML4-ALK V1 [G1269A]/BaF3
CBP73341EML4-ALK V1 [G1202R/G1269A/L1198F]/BaF3
CBP73340EML4-ALK V1 [G1202R/G1269A/L1204V]/BaF3
CBP73339EML4-ALK V1 [I1171N/L1198H]]/BaF3
CBP73301EML4-ALK V1 [I1171N/F1174I]/BaF3
CBP73300EML4-ALK V1 [I1171N]/BaF3
CBP73299EML4-ALK V1 [G1202R/G1269A] /BaF3
CBP73273EML4-ALK V1 [G1202R/L1198F] /BaF3
CBP73272EML4-ALK V1 [G1202R/L1196M] /BaF3
CBP73271EML4-ALK V1 [G1202R]/BaF3
CBP73200EML4-ALK V3a/BaF3
CBP73199EML4-ALK V1 [C1156Y]/BaF3
CBP73189EML4-ALK V1 [F1174L]/BaF3
CBP73188EML4-ALK V1 [L1196M]/BaF3
CBP73187EML4-ALK V3b/BaF3
CBP73186EML4-ALK V1/BaF3
CBP73185
掃二維碼
